National Centers for Systems Biology

Tools, Reagents & Organisms

Center for Genome Dynamics (The Jackson Laboratory)

Mouse Diversity Genotyping Array
Mouse Diversity Genotyping Array is the most advanced high-density mouse genotyping microarray available. It was designed by Center for Genome Dynamics investigators Drs. Fernando Pardo-Manuel de Villena and Gary Churchill.

Center for Modular Biology (Harvard University)

Indel arrays for genotyping of Arabidopsis populations
Available genotyping approaches for Arabidopsis mapping populations such as PCR and whole genome-microarrays are either very labor intensive or prohibitively expensive. To meet this challenge, we have developed a novel genotyping array which combines the advantages of high-throughput genotyping with the precision of PCR.  In addition to detailed method descriptions, printed arrays are available at cost to academic researchers at www.cgr.harvard.edu/Queitschlab/index.html

Two-component clone sets and deletion strains for Caulobacter crescentus
The following clone sets and deletion collections are available on request by email:
1) Deletion mutant collection for the 106 C. crescentus two-component signal transduction genes.
2) Sequence-verified Gateway pENTR clones for each C. crescentus response regulator gene.
3) Sequence-verified Gateway pENTR clones for each E. coli response regulator gene.

Skerker, J., Prasol, M., Perchuk, B., Biondi, E. & Laub, M. Two-component signal transduction pathways regulating growth and cell cycle progression in a bacterium: a system-level analysis. PLoS Biol. 3, e334 (2005). [PDF]

Center for Systems Biology (Institute for Systems Biology)

Sharing Model Organisms. In the course of our research the Center expects to generate a number of new strains of Halobacterium salinarum and Saccharomyces cerevisiae. We will distribute these strains freely upon publication. Available strains will be publicized on our Center website, as well as in any scientific publications arising from this work. Strain requests will be made via the Center website or by contacting the individual investigators (contact emails are listed on the Center website). These investigators have established H. salinarum or yeast biology labs with significant experience in maintaining and distributing these strains in a timely fashion. Should the number of strains generated or the number of requests for individual strains exceed the capacity to distribute them, the strains will be deposited in a strain repository, such as the ATCC or Open Biosystems.