Center for Systems and Synthetic Biology (UC San Francisco)
Principal investigator: Wendell Lim, Ph.D., University of California San Francisco (UCSF)
Other key investigators: Chao Tang, Nevan Krogan, Hana El-Samad, Hao Li, Alma Burlingame (UCSF); Jasper Rine (UC Berkeley)
The UCSF Center for Systems and Synthetic Biology is combining the approaches for forward and reverse biological engineering to gain a deeper understanding of the mechanisms by which cellular networks solve physiological problems in signal processing and regulation. We are mapping complex regulatory networks involved in cell signaling and metabolic regulation; comparing these networks across species; computationally mapping the relationship between network architecture and function; and building and exploring combinatorial network libraries for diverse modular functions. We are interested in the following questions:
- how are molecular components in cellular networks organized to yield complex biological function?
- are there common evolutionary solutions to core biological problems?
- can we understand how network breakdown leads to disease?
- can we utilize these emerging design principles to engineer biological systems to solve problems in health, energy and environment?